A Prion-like Trigger of Antiviral Signaling
نویسندگان
چکیده
The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self-aggregates that provide a sensitive trigger for antiviral signaling.
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ورودعنوان ژورنال:
- Cell
دوره 146 شماره
صفحات -
تاریخ انتشار 2011